To investigate depressive and anxious symptomatology among transitioning adolescents and college students with ADHD, dyslexia, or comorbid ADHD/dyslexia. Transitioning adolescents and college students with these disorders along with a non-ADHD/dyslexia college sample completed self-report measures of depression and anxiety. Results indicated no differences between the college-level groups, although a main effect for gender was found and trended toward females with dyslexia reporting more symptoms of depression and anxiety than did males with dyslexia. Internalizing symptomatology differences were not found for subtypes of ADHD. Transitioning high school students with ADHD, dyslexia, or ADHD/dyslexia reported fewer symptoms of anxiety and depression than did college underclassmen with these disorders. The unique characteristics and experiences of the college population of individuals with ADHD and/or dyslexia are discussed relative to the general adult population with these disorders.